The 2008 Eisner nominations have been announced. You can see them all here on The Beat. This year has an especially large number of things I haven't read, but I can call out two people I'd like to see win:
Ed Brubaker, for Best Writer
Pia Guerra and Jose Marzan, Jr., for Best Penciller/Inker Team
I'm a fan of Pia (nose around my site to see how I first met up with her), and I think Ed Brubaker should be encouraged to write more excellent crime comics (or really, anything else he wants to, but I always pick up his crime stuff). So I recommend both of them, but am otherwise Eisner-agnostic.