The difference between computational biology and lab biology?
Fifteen-hour days.
There are other differences, though. Working in lab is honestly more fun, and leaves me feeling more energetic at the end of that (very long) day than does a typical day in front of the computer.
Even if one of my centrifuge tubes cracked and I had to pour sample out of the rotor. And then scrape semi-frozen yeast slurry off the inside of the centrifuge.